The major activemetabolites of testosterone are estradiol and DHT. Approximately 40% of testosterone in plasma is bound to SHBG, 2%remains unbound (free) and the rest is loosely bound to albumin and otherproteins. Circulating testosterone isprimarily bound in the serum to sex hormone-binding globulin (SHBG) and albumin. Male hypogonadism, a clinicalsyndrome resulting from insufficient secretion of testosterone, has two mainetiologies. This subject had serum testosteroneconcentrations of up to 11,400 ng/dL, which were implicated in acerebrovascular accident. There is a single report in the literature of acute overdosageafter injection of testosterone enanthate. The high doses of testosterone required to increase sexual desire in women may have a significant risk of masculinization with long-term therapy. Because of a lack data to support its efficacy and safety, the Endocrine Society recommends against the routine use of testosterone in women to treat low androgen levels due to hypopituitarism, adrenal insufficiency, surgical removal of the ovaries, high-dose corticosteroid therapy, or other causes. With single daily applications of testosterone gel 50 mgand 100 mg, follow-up measurements at 30 and 90 days after starting treatmenthave confirmed that serum testosterone and DHT concentrations are generallymaintained within the normal range. With large doses of exogenous androgens, includingVogelxo, spermatogenesis may be suppressed through feedback inhibition ofpituitary follicle-stimulating hormone (FSH) which could possibly lead toadverse effects on semen parameters including sperm count. RxList does not provide medical advice, diagnosis or treatment. There may be new information.This leaflet does not take the place of talking to your healthcare providerabout your medical condition or treatment. Read this Instructions for Use for Vogelxo before youstart using it and each time you get a refill. You can ask your pharmacist or healthcare provider forinformation about Vogelxo that is written for health professionals. Do not use Vogelxo for a condition forwhich it was not prescribed. General information about the safe and effective useof Vogelxo. Call your healthcare provider right away if you haveany of the serious side effects listed above.
